MD+ & MSU-MD
The MegaSD supports adding CD audio to existing Genesis / Mega Drive roms using special patches. There are multiple formats out there to do this. TerraOnion created the MD+ format which currently only works on the MegaSD cartridge. it allows for seamless looping and fade-in/fade-out effects. There is an older format, Mode 0, that similarly allows CD audio to be added to games but it doesn't have all of the advanced features. MSU-MD, the format that is supported by the Everdrive Pro, is based on this format. The benefit to Mode 0 / MSU-MD is that it allows you to burn a CD and use the enhanced audio on real hardware.